Corrosive substance: risk of internal burns if ingested. Toxicology : Oral – rat LD50: 49 mg/kg Eye : Corrosive, contact causes severe eye burns which may result in permanent tissue and corneal damage. Skin : Corrosive causes skin burns and severe irritation. Inhaled : Corrosive. Severe irritant to respiratory tract. Possible systemic effects.

There is no specific concentration limit applicable to the sensitising substance. The percentage of the sensitiser is below the generic concentration limit (of ≥1.0%) in Table 3.4.5 of Annex I of the EC Regulation 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP) that would trigger the classification of the mixture as a respiratory sensitiser, but above the concentration …

Sensitisers are substances that can cause an allergic reaction. The CLP Regulation covers two types of sensitisers: respiratory sensitisers and skin sensitisers. Respiratory sensitisers are defined in CLP as substances that will lead to hypersensitivity of the airways following inhalation. Dictionary entry overview: What does sensitiser mean?

Sensitiser on a bottled substance

For substances which produce signs of immunological contact urticaria but which do not fulfil the criteria as a respiratory sensitiser, consideration shall be given to classification as a skin sensitiser. Context Ref. Annex I, Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008, 32008R1272/EN undertaken for substances already classified as sensitisers however. In this case any hazard assessment as to whether the substance indeed is a respiratory and/or skin sensitiser and to which CLP category it may belong is not necessary anymore. It will suffice to compare the potential impacts OBJECTIVES: 3-(Bromomethyl)-2-chloro-4-(methylsulfonyl)-benzoic acid (BCMBA) has not previously been identified as a respiratory sensitiser. We detected two cases who presented respiratory and urticaria symptoms related to BCMBA and had positive skin prick tests to the agent. In Canada, the Controlled Products Regulations (CPR) define a pure substance or tested mixture as a respiratory tract sensitizer—if there is evidence that shows that it causes respiratory tract sensitization in persons following exposure to it in the work place.

Eliminate or substitute harmful substances Replace the skin sensitiser or modify the work process to avoid 2019-12-17 · For most substances, there’s more than one route of administration. In particular, cocaine can either be insufflated or snorted through the nose, when it’s in powdered form. Alternately, there’s a freebase form of cocaine, which requires the drug to be solid so that it can be placed on a piece of foil with heat being applied from the underside of the foil.

We found one answer for “Sensitiser” . This page shows answers to the clue Sensitiser.Sensitiser may be defined as “See Respiratory Sensitiser and Allergic Dermatitis” and “A substance that causes dermatitis only after alteration (sensitization) of the skin by previous exposure to that substance”.

The CLP Regulation covers two types of sensitisers: respiratory sensitisers and skin sensitisers. Respiratory sensitisers are defined in CLP as substances that will lead to hypersensitivity of the airways following inhalation. Labelling of sensitiser containing mixture We have a non-gaseous product that is supplied to the general public and which contains in the mixture a low percentage of aromatic oil that is classified as a respiratory sensitiser of Category 1B.

Hazardous Substances Data Bank (HSDB) Bisphenol A can leach from beverage bottles and coated water pipes that can then be consumed. is rarely reported, and in only 2 cases was BPA considered to be the responsible sensitizer.

However, a few substances, such as rosin, are capable of this double allergenic role.

A skin sensitiser refers to a substance that will lead to an allergic response following 72 repeated skin contact as defined by the United Nations Globally Harmonized System of 73 Classification and Labelling of Chemicals (UN GHS) (1). There is general agreement on 74 the key biological events underlying skin sensitisation. JUSTIFICATION DOCUMENT FOR THE SELECTION OF A CORAP SUBSTANCE _____ EC no 404-740-9 MSCA - Slovenia Page 5 of 6 4 JUSTIFICATION FOR THE SELECTION OF THE CANDIDATE C O RAP SUBSTANCE 4.1 Legal basis for the proposal Article 44(2) (refined prioritisation criteria for substance evaluation) Article 45(5) (Member State priority) For a substance like CMIT/MIT that has a specific concentration limit of 0.0015% (15 ppm), chemical mixtures have to be classified as skin sensitisers from 0.0015% (with the CLP label elements) and between 0.00015 (1.5 ppb) and 0.0015% (15 ppb) the EUH208 sentence has to 2014-10-15 · Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of formaldehyde as preservative in feedingstuffs for all animal species. The additive formaldehyde is an aqueous solution containing 35 % formaldehyde and 14 % methanol. CORAP SUBSTANCE 8 5.1. Legal basis for the proposal 8 5.2. Selection criteria met (why the substance qualifies for being in CoRAP) 8 5.3.
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However, a few substances, such as rosin, are capable of this double allergenic role. A sensitiser is a substance that can induce an 'over-reaction' of the body's immune system. A sensitiser must first penetrate the skin (most contact sensitisers are small molecules with molecular weights below 1000).

Alternately, there’s a freebase form of cocaine, which requires the drug to be solid so that it can be placed on a piece of foil with heat being applied from the underside of the foil. Quick definitions from WordNet (sensitiser) noun: (chemistry) a substance other than a catalyst that facilitates the start of a catalytic reaction Medical definition of sensitizer: one that sensitizes: as. Carcinogen . Carcinogen means a substance or a mixture of substances which induce cancer or increase its incidence.
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A chemical is classified as a skin sensitizer if there is evidence in humans that the substance can lead to sensitization by skin contact in a substantial number of persons, or if there are positive results from an appropriate animal test. Skin sensitizers are categorized as Category 1A or 1B.

A contact sensitiser is a substance that will induce an allergic response following skin contact. CONSIDERATIONS 3.

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There is no specific concentration limit applicable to the sensitising substance. The percentage of the sensitiser is below the generic concentration limit (of ≥1.0%) in Table 3.4.5 of Annex I of the EC Regulation 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP) that would trigger the classification of the mixture as a respiratory sensitiser, but above the concentration level (of ≥0.1%) in Table 3.4.6 of CLP Annex I for elicitation.

type of: activator. (biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene Princeton's WordNet (3.00 / 1 vote) Rate this definition: sensitizer, sensitiser (noun) (chemistry) a substance other than a catalyst that facilitates the start of a catalytic reaction.

Corrosive substance: risk of internal burns if ingested. Toxicology : Oral – rat LD50: 49 mg/kg Eye : Corrosive, contact causes severe eye burns which may result in permanent tissue and corneal damage. Skin : Corrosive causes skin burns and severe irritation. Inhaled : Corrosive. Severe irritant to respiratory tract. Possible systemic effects.

The proposal covers the substances which are classified as skin sensitisers in Category 1 or 1A or 1B in Annex VI to Regulation (EC) No 1272/2008, as well as a list of disperse dyes that are indicated to have skin We found one answer for “Sensitiser” . This page shows answers to the clue Sensitiser.Sensitiser may be defined as “See Respiratory Sensitiser and Allergic Dermatitis” and “A substance that causes dermatitis only after alteration (sensitization) of the skin by previous exposure to that substance”. most likely to touch the substance, but may spread to other parts of the body. Early signs include dryness, redness and itching of the skin. The skin may become swollen, cracked, scaly and thickened and blisters may develop. How quickly a skin reaction develops depends on the strength or potency of the substance and how long and how often it touches Antibiotic sensitivity testing or antibiotic susceptibility testing is the measurement of the susceptibility of bacteria to antibiotics.It is used because bacteria may have resistance to some antibiotics.

A closed bottle of unused potassium dichromate-sulfuric acid mixture explod (2) The efficient functioning of the internal market for substances can be achieved as a respiratory sensitiser, or in respect of other effects on a case-by-case basis. (e.g. liquid gas bottles);(d)artists' paints covered by D SENSITISER (noun) The noun SENSITISER has 1 sense: 1. (chemistry) a substance other than a catalyst that facilitates the start of a catalytic reaction play. Jan 2, 2009 be assessed under both COSHH and the Dangerous Substances Solvent or acid Winchester bottles should not be carried by the neck, but HSE Respiratory sensitisers and COSHH http://www.hse.gov.uk/pubns/indg95.pdf. Sep 9, 2020 associated with chemical substances.